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Ubiquitin-protein ligases (E3s) act as molecular switches that regulate diverse processes by targeting specific substrates for ubiquitination and subsequent degradation. Tankyrase 1 (TNKS1), which consists of ankyrin repeats, is a ubiquitin-protein ligase that specifically targets the protein kinase, PARP1, for poly(ADP-ribosyl)ation and degradation. The relationship between TNKS1 and PARP1 has been identified as a tumor suppressor gene in mice. We investigated the expression pattern of TNKS1 in several human cancer cell lines and analyzed its function in cell cycle progression. High levels of TNKS1 were observed in several cancer cell lines and its expression was downregulated by knockdown of TNKS1. TNKS1 knockdown induced premature entry into S-phase in G1- and G2-phase cells and accelerated the degradation of the endogenous PARP1 protein in G2-phase cells. These results suggest that TNKS1 functions in cell cycle progression as a cell cycle regulatory protein.Huge number of artworks seized
An inventory of artworks seized from the Nigeria Customs Service, CBN is likely to be on sale in Nigeria by October.
The director general of the Customs, Enyinnaya Abaribe, while inspecting the recently completed inventory of seized property at the Custom House in Apapa, Lagos, stated that the entire inventory would be sold in Nigeria by October.
Mr Abaribe stated that he was all set to sell all the artworks seized from smugglers and criminals.
While inspecting the seized property, Mr Abaribe said that the destruction of the artworks would be done by the art specialists of the CBN and they would not be damaged in any way.
He said that the CBN did not want to devalue the value of the pieces as it did not want them to fall into the hands of non-nigerians